ea0020p183 | Endocrine tumours and neoplasia | ECE2009
Corbetta Sabrina
, Vaira Valentina
, Guarnieri Vito
, Scillitani Alfredo
, Eller-Vainicher Cristina
, Vicentini Leonardo
, Chiodini Jacopo
, Bisceglia Michele
, Beck-Peccoz Paolo
, Bosari Silvano
, Spada Anna
Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Though the loss of the oncosuppressor HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic parathyroid carcinomas, parathyroid carcinogenesis remains obscure. MicroRNAs (miRNAs) are a new class of small, non-coding RNAs implicated in embryonic development and cancer. A deregulated miRNA can induce the aberrant expression ...